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In a study of 14 healthy females, pretreatment with an MAO-A inhibitor decreased imitrex the clearance of subcutaneous sumatriptan .
Under the conditions of this experiment, the imitrex result was a 2-fold increase in the area under the sumatriptan plasma concentration x time curve (AUC), corresponding to a 40% increase in elimination half-life .
This imitrex interaction was not evident with an MAO-B inhibitor .
A small study evaluating the effect of pretreatment with an MAO-A inhibitor on the bioavailability from a 25-mg oral sumatriptan tablet resulted in an approximately 7-fold increase imitrex injection route sumatriptan injection ndc imitrex to get high imitrex nsaid imitrex and in systemic exposure .
1% w/v), a decongestant, administered 15 minutes prior to a 20-mg imitrex nasal dose of sumatriptan did not alter the pharmacokinetics of sumatriptan . Xylometazoline: An in vivo drug interaction study indicated that imitrex 3 drops of xylometazoline (0 .
The efficacy of IMITREX Nasal Spray in the acute treatment of migraine headaches was demonstrated in 8, randomized, double-blind, placebo-controlled studies, of which 5 used the recommended dosing regimen and imitrex used the marketed formulation .
Patients enrolled in these 5 studies were predominately female (86%) and Caucasian (95%), with imitrex a mean age of 41 (range of 18 to 65) .
Patients were imitrex instructed to treat a moderate to severe headache .
Headache response, defined as a reduction in headache imitrex severity from moderate or severe pain to mild or no pain, was assessed up to 2 hours after dosing .
Associated symptoms such as nausea, imitrex photophobia, and phonophobia were also assessed .
Maintenance of response imitrex was assessed for up to 24 hours postdose .
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