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Gastrointestinal (GI) Effects- Risk of GI Ulceration, Bleeding, and Perforation: Serious gastrointestinal toxicity celecoxib such as bleeding, ulceration, and perforation of the stomach, small intestine or large intestine, can occur at any time, with or without warning symptoms, in patients treated with nonsteroidal anti-inflammatory drugs (NSAIDs) .
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