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Bone marrow purinethol examination may also be useful for the evaluation of marrow status .
The decision to increase, decrease, continue, or discontinue a given dosage of PURINETHOL must purinethol bijwerking purinethol foie long term purinethol use purinethol medication purinethol be based upon the degree of severity and rapidity with which changes are occurring .
In many instances, particularly during the induction phase of acute leukemia, complete blood counts will need to be done more frequently than once weekly purinethol in order to evaluate the effect of the therapy .
If a patient has clinical purinethol or laboratory evidence of severe bone marrow toxicity, particularly myelosuppression, TPMT testing should be considered .
Genotypic and phenotypic testing purinethol of TPMT status are available .
Genotypic testing can determine the purinethol allelic pattern of a patient .
Currently, 3 alleles—TPMT*2, TPMT*3A purinethol canada purinethol bij crohn purinethol fever purinethol en colitis purinethol in korea and TPMT*3C— account for about 95% of individuals with reduced levels of TPMT activity .
Individuals homozygous for these alleles are purinethol lait purinethol immune system purinethol aspen pharma purinethol tbl purinethol et TPMT deficient and those heterozygous for these alleles have variable TPMT (low or intermediate) activity .
Phenotypic testing determines the level purinethol drug class purinethol gelenkschmerzen purinethol monograph ziek van puri nethol of thiopurine nucleotides or TPMT activity in erythrocytes and can also be informative .
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