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5% Methylcellulose Gavage Studies Plasma carisoprodol carisoma concentrations were measured in rats and mice at the end of the studies .
Blood was collected from the retroorbital sinus of half of the surviving rats and mice from each of the dosed groups 30 minutes after the last dose was administered and from the remaining animals at 60 minutes STATISTICAL METHODS Calculation and Analysis carisoma of Lesion Incidences The incidences of lesions are presented in Appendix A as the numbers of animals bearing such lesions at a specific anatomic site and the numbers of animals with that site examined microscopically .
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Organ and body weight data, which have approximately normal distributions, were analyzed carisoma with the parametric multiple comparison procedures of Dunnett (1955) and Williams (1971, 1972) .
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Jonckheere’s test (Jonckheere, 1954) carisoma was used to assess the significance of the doserelated trends and to determine whether a trend-sensitive test (Williams’ or Shirley’s test) was more appropriate for pairwise comparisons than a test that does not assume a monotonic dose-related trend (Dunnett’s or Dunn’s test) .
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