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purinethol Renal clearance may become important at high doses . CCO Formulary – August 2016 Active metabolites thioguanine nucleotides, methylated Inactive metabolites purinethol et colite ulcereuse purinethol remicade purinethol side effects ulcerative colitis At conventional doses clearance is primarily hepatic and by xanthine oxidase, which is the main catabolic enzyme .
7% of oral dose excreted unchanged in 12 90 minutes; active metabolites longer C – Indications and Status Health Canada Approvals: Maintenance therapy of acute lymphocytic or lymphoblastic leukemia as part of a combination Acute promyelocytic leukemia (APL) as part of a combination regimen D – Adverse Effects Emetogenic Potential: Minimal Extravasation Potential: Not applicable SIDE EFFECT* (%) purinethol Radiation recall reaction (facial edema; rare) Any use of the information is subject, at all times, to CCO’s Terms and Conditions .
CCO Formulary – August 2016 Gastrointestinal Hypersensitivity Skin discolouration Nausea, vomiting (23%) Immunosuppression /atypical infection Myelosuppression ± infection, bleeding (may be severe) ↑ LFTs (40%) (may be severe) Pancreatitis (rare) Hypersensitivity (fever, arthralgia) Metabolic / Endocrine Tumor lysis syndrome purinethol Secondary malignancy (leukemia/lymphoma; rare) Crystalluria (high IV doses) Hemorrhage (high IV doses) * “Incidence” may refer to an absolute value or the higher value from a reported range .
“Rare” may refer to events with < 1% incidence, reported in post-marketing, phase 1 studies, purinethol sperm side effects from purinethol purinethol and alcohol interaction obat purinethol isolated data or anecdotal reports .
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