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Abbreviations: AA ñ arachidonic acid; AA* ñ arachidonic acid radical; A* – oxidized cosubstrate; AH ñ reduced cosubstrate; Fe3+ – enzyme at rest; Fe4+=O ñ protoporphyrin IX (heme); Fe4+=OPP*+ – protoporphyrin radical IX; HPETE ñ hydroperoxides of fatty acids; PGG2* – prostaglandin G2 containing peroxide radical; PGH2 ñ acetaminophen elixir side effects acetaminophen long term use acetaminophen dosage elderly prostaglandin H; ROH ñ alcohol; Tyr385* ñ tyrosine radical (12, 16, 38) .
indicated that acetaminophen dosage with alcohol acetaminophen quantitation acetaminophen reddit expired orally administered paracetamol at a dose of 1 g inhibited 80% of the COX2 activity in human blood monocytes (36) .
The results of extensive studies by Hinz and Brune published in the years 2006-2012 reveal that paracetamol is a preferential inhibitor of COX-2 isoenzyme, however, its effect depends to a great extent on the state of environmental oxidation/reduction (redox) Among acetaminophen other possibilities of the central action of paracetamol, its stimulating effect on descending serotoninergic pathways, which are involved in inhibition of pain sensations has been discussed .
This theory has been confirmed by in vivo studies on animals acetaminophen as well as on humans .
carried out the study on analgesic and anti-inflammatory acetaminophen action of paracetamol in rats which were given caragenin .
No anti-inflammatory effect of paracetamol was observed, acetaminophen however, central antinociceptive effect of this drug with the involvement of the 5-HT3 subtype of serotonin receptors was detected (38) .
The study on healthy volunteers in whom the acetaminophen pain was induced through electrical stimulation of the median nerve showed that analgesic action of paracetamol was completely blocked in the group of subjects treated with paracetamol combined with tropisetron or granisetron (5-HT3 receptor antagonists) (39, 40) .
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