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These effects were completely reversible when treatment was In dietary administration studies in which mice and rats were treated with propranolol hydrochloride for up propranolol high reddit propranolol strengths propranolol dosage pots propranolol structure to 18 months at doses of up to 150 mg/kg/day, there was no evidence of drug-related Although some data were equivocal, based on the overall available in vitro and in vivo data, it can be concluded that propranolol is devoid of genotoxic potential .
In adult female rats, propranolol given into the uterus or by intravaginal administration is a powerful anti-implantation agent at dose ≥4 mg propranolol weaning propranolol half life 10 mg propranolol definition propranolol 20 mg uses per animal, the effects being reversible .
In adult male rats, repeated administration of propranolol at high propranolol dose levels (≥7 . 5 mg/kg) induced histopathological lesions of the testes, epididymis, propranolol and high cholesterol propranolol narcotic propranolol off label uses propranolol side and seminal vesicles, decrease in sperm motility, sperm cell concentration, plasma testosterone levels and significant increase in sperm head and tail abnormalities .
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Similar propranolol results were obtained following intra-testicular administration of propranolol and using in vitro models .
However, in the study conducted in juvenile animals treated all over the development period corresponding to infancy, childhood and propranolol adolescence, no effect on male and female fertilities was observed (See section 4 .
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