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Therapeutic plavix Effects: Decreased occurrence of atherosclerotic events in patients at risk .
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Parent drug has no plavix antiplatelet activity .
Protein Binding: Clopidogrel— 98%; plavix active metabolite— 94% .
Metabolism and Excretion: Rapidly and extensively converted by the liver (CYP2C19) to its active metabolite, which is then eliminated 50% in urine and 45% in feces; 2% of Whites, 4% of Blacks, and 14% of Asians have CYP2C19 genotype plavix that results in reduced metabolism of clopidogrel (poor metabolizers) into its active metabolite (may result inpantiplatelet effects) .
plavix Half-life: 6 hr (active metabolite 30 min) .
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GI: GI plavix BLEEDING, abdominal pain, diarrhea, dyspepsia, gastritis .
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