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Carcinogenesis, mutagenesis, impairment of fertility: Celecoxib was not carcinogenic in rats given oral doses up to 200 mg/kg for males and 10 mg/kg for females (approximately 2- to 4-fold the human exposure as measured by the AUC0-24 at 200 mg BID) or in mice given oral doses up to 25 mg/kg for males and 50 mg/kg for females (approximately equal to human exposure as measured by the AUC0-24 at 200 mg BID) for Celecoxib was not mutagenic in an Ames test and a mutation assay in Chinese celebrex hamster ovary (CHO) cells, nor clastogenic in a chromosome aberration assay in CHO cells and an in vivo micronucleus test in rat bone marrow .
Celecoxib did not impair male and female fertility in rats at celebrex oral doses up to 600 mg/kg/day (approximately 11-fold human exposure at 200 mg BID based on the Teratogenic effects: Pregnancy Category C .
celebrex Celecoxib at oral doses ≥150 mg/kg/day (approximately 2-fold human exposure at 200 mg BID as measured by AUC0-24), caused an increased incidence of ventricular septal defects, a rare event, and fetal alterations, such as ribs fused, sternebrae fused and sternebrae misshapen when rabbits were treated throughout organogenesis .
A dose-dependent increase in diaphragmatic hernias was observed when rats were given celecoxib at oral doses ≥30 mg/kg/day side effects of celebrex in the elderly celebrex 10mg celebrex benefits is celebrex a steroid how (approximately 6fold human exposure based on the AUC0-24 at 200 mg BID) throughout organogenesis .
There are no studies in pregnant is celebrex an over the counter drug can you take ibuprofen with celebrex celebrex and blood women .
CELEBREX should be used during pregnancy celebrex only if the potential benefit justifies the potential risk to the fetus .
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