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HOW MUCH IS 50 OR 90 MME/DAY FOR COMMONLY PRESCRIBED OPIOIDS? 50 mg of hydrocodone (10 tablets of hydrocodone/ acetaminophen 5/300) 90 mg of hydrocodone (9 tablets of hydrocodone/ acetaminophen 10/325) 33 mg of oxycodone (~2 tablets of oxycodone sustained-release 15 mg) 60 mg of oxycodone (~2 tablets of oxycodone sustained-release 30 mg) 12 mg of methadone ( <3 tablets of methadone 5 mg) ~20 mg of methadone morphine mechanism of action morphine end of life morphine equivalent morphine morphine respiratory (4 tablets of methadone 5 mg) L E A R N M O R E | www . html HOW SHOULD THE TOTAL DAILY DOSE OF OPIOIDS BE CALCULATED? DETERMINE the total morphine daily amount of each opioid the patient takes .
CONVERT each to MMEs—multiply morphine bottle size morphine hospice dosage morphine vs hydrocodone morphine availability morphine the dose for each opioid by the conversion factor .
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Calculating morphine milligram equivalents (MME) OPIOID (doses in mg/day except where noted) CONVERSION morphine FACTOR Fentanyl transdermal (in mcg/hr) These dose conversions are estimated and cannot account for all individual differences in genetics and pharmacokinetics .
USE EXTRA CAUTION: • morphine refrigerate morphine administration morphine sublingual absorption morphine morphine Methadone: the conversion factor increases at Do not use the calculated dose in MMEs to determine dosage for converting one opioid to another—the new opioid should be lower to avoid unintentional overdose caused by incomplete cross-tolerance and individual differences in opioid pharmacokinetics .
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