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Coadministration of erythromycin and a drug primarily metabolized by CYP3A may be associated with elevations in drug concentrations that could increase or prolong both the therapeutic and adverse effects of the concomitant erythromycin drug .
erythromycin Dosage adjustments may be considered, and when possible, serum concentrations of drugs primarily metabolized by CYP3A should be monitored closely in patients concurrently receiving erythromycin .
The erythromycin following are examples of some clinically significant CYP3A based drug interactions .
Interactions with other drugs metabolized by the erythromycin topical gel erythromycin topical erythromycin base erythromycin estolate erythromycin CYP3A isoform are also possible .
The following CYP3A based drug interactions have been observed with erythromycin erythromycin products in post-marketing experience: Ergotamine/dihydroergotamine Post-marketing reports indicate that co-administration of erythromycin with ergotamine or dihydroergotamine has been associated with acute ergot toxicity characterized by vasospasm and ischemia of the extremities and other tissues including the central nervous system .
Concomitant administration of erythromycin with ergotamine or erythromycin dosage erythromycin drug erythromycin base erythromycin acne erythromycin prescription dihydroergotamine is contraindicated (see CONTRAINDICATIONS) .
Triazolobenzodiazepines (such as triazolam and alprazolam) and related benzodiazepines Erythromycin has been reported to decrease the erythromycin drug erythromycin dosage erythromycin acne erythromycin ophthalmic erythromycin clearance of triazolam and midazolam, and thus, may increase the pharmacologic effect of these benzodiazepines .
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