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6 However, oxymorphone has a significantly longer half life (7-9 hours)7 than does oxycodone, whose mean elimination half-life methadone following a single, oral dose is 3 . methadone 43 hours . methadone effects on the brain methadone classification methadone for opiate addiction methadone 51 � 1 . Oxycodone is metabolized in part by cytochrome P450 2D6 to oxymorphone, methadone which represents less than 15% of the total administered dose .
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