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CATAPRES 100 PI0046b-06 Clonidine had no effect on fertility in male or female rats when administered clonidine orally at doses up to 0 . 15 mg/kg/day (35% higher than the maximum recommended total daily clonidine dose of clonidine in humans, based on body surface area) .
Use in Pregnancy (Category B3) Clonidine hydrochloride has not shown teratogenic potential when tested in rats, but in some circumstances the incidence of embryonic and perinatal deaths was increased with doses comparable to those used clonidine clinically for antihypertensive therapy .
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