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1 Clinical pharmacology Unlike methadone, the effect of buprenorphine on respiratory depression reaches a ceiling, with higher buprenorphine products buprenorphine treatment buy suboxone online cheap buprenorphine patch high doses not increasing respiratory depression to a significant degree .
However, if buprenorphine is used in combination with other central nervous system depressants, such buprenorphine as benzodiazepines, the combined effect on respiration can be life threatening .
Buprenorphine also exhibits antagonist effects at the kappa (k) opioid buprenorphine receptor .
The buprenorphine role of these receptors in humans is still poorly understood .
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