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Dosing in Patients with Renal Impairment Table 8 Pramipexole Dosage in Parkinson’s Disease Patients with Renal Impairment Normal to mild impairment (creatinine Cl > 60 mL/min) Moderate impairment (creatinine Cl = 35 to 59 mirapex mL/min) Severe impairment (creatinine Cl = 15 to 34 mL/min) Very severe impairment (creatinine Cl < 15 mL/min and hemodialysis patients) The use of MIRAPEX tablets has not been adequately studied in this group of patients .
NDA 20-667/S-014, S-017 and S-018 Discontinuation of Treatment It is recommended that MIRAPEX tablets be discontinued over a period of 1 week; in mirapex some studies, however, abrupt discontinuation was uneventful .
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