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Norfloxacin did not adversely affect the fertility of male and female mice at oral doses up to 30 times*** the noroxin oftalmico noroxin infeccion urinaria norfloxacin dose per day noroxine 400 et grossesse usual human dose (on a mg/kg basis) .
Norfloxacin has been shown to produce embryonic loss in monkeys when given in doses 10 times*** the maximum daily total human dose (on a mg/kg noroxin basis) .
noroxin At this dose, peak plasma levels obtained in monkeys were approximately 2 times those obtained in humans .
There has been noroxin no evidence of a teratogenic effect in any of the animal species tested (rat, rabbit, mouse, monkey) at 6-50 times*** the maximum daily human dose (on a mg/kg basis) .
There are, however, no adequate and noroxin well-controlled studies in pregnant women .
Norfloxacin should noroxin be used during pregnancy only if the potential benefit justifies the potential risk to the fetus .
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