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Food increases oral bioavailability of selegiline 3- to 5-fold but does not appear to affect the pharmacokinetics emsam of the first-pass metabolites .
Special Populations Following administration of a single 10-mg dose in a limited number of adults ?60 years emsam of age, systemic exposure was twice that reported in adults 18�30 years of age .
Selegiline emsam and its metabolites are widely distributed into body tissues .
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Selegiline and/or its zyvox coverage zyvox injection zyvox coverage zyvox tablet zyvox antibiotic side effects zyvox zyvox metabolites also detected in the liver and hair .
Plasma cost of zyvox 600 mg iv zyvox prescribing information zyvox drug class what is zyvox used to treat Protein Binding Selegiline and/or its metabolites: Up to 94% .
Extensively metabolized, principally in the gut wall and liver, to l-desmethylselegiline and emsam l-methylamphetamine (CYP-mediated) and then to l-amphetamine .
The amphetamine emsam metabolites may be hydroxylated and then conjugated with glucuronic acid .
l-Desmethylselegiline is an irreversible inhibitor of MAO-B, but its contribution to MAO-B inhibition during emsam selegiline therapy may be only minor .
The levorotatory amphetamine what is zyvox zyvox contraindications zyvox drug zyvox indications zyvox pfizer zyvox antibiotic isomers are less potent CNS stimulants than the racemic or dextrorotatory isomers .
Elimination Route Excreted principally in urine as conjugated and unconjugated metabolites (20�63% zyvox 600 zyvox 600 mg iv zyvox renal dosing what is zyvox 600 mg used for zyvox generic cost of as l-methamphetamine, 9�26% as l-amphetamine, and 1% as l-desmethylselegiline ) .
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