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However, it soon appeared acetaminophen dosage kid acetaminophen cardiac side effects acetaminophen mapap acetaminophen brands that so sensitive to paracetamol COX-3 does not function in the human organism .
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Thus, COX-3 involvement in the mechanism of action of paracetamol in humans has not acetaminophen been justified, which has been confirmed by Kis et al .
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Firstly, the studies by Graham and Scott have shown that paracetamol really inhibited prostaglandin synthesis in well-functioning cells, however, it did not exert the same effect in the tissue/cell homogenate, acetaminophen side effects pregnancy acetaminophen vs aspirin acetaminophen side effects sleepy where the concentration of arachidonic acid is low (35) .
Secondly, paracetamol has been found to have an inhibitory impact on COX-1 acetaminophen zquil acetaminophen tablet dosage acetaminophen joint swelling acetaminophen effects and COX-2 activity in peripheral tissues, although not to the same extent, since a stronger effect was always observed in relation to COX-2, especially in the cells of the vascular endothelium .
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