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The long elimination half-lives of fluoxetine and norfluoxetine prozac assure that, even when dosing is stopped, active drug substance will persist in the body for weeks (primarily depending on individual patient characteristics, previous dosing regimen, and length of previous therapy at discontinuation) .
This is of potential consequence when drug discontinuation is required or when drugs are prescribed prozac that might interact with fluoxetine and norfluoxetine following the discontinuation of PROZAC .
Weekly Dosing — Administration of PROZAC Weekly once weekly results in increased fluctuation between peak and trough concentrations of fluoxetine and norfluoxetine compared with once-daily dosing [for fluoxetine: 24% (daily) to prozac generic what is prozac prescribed for in adults long term use of prozac side effects best 164% (weekly) and for norfluoxetine: 17% (daily) to 43% (weekly)] .
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