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Increased intrauterine and post-natal mortality and procoralan cardiac malformations were observed at doses ≥ 2 . 3 mg/kg/day (equivalent to procoralan the human exposure at the MRHD based on AUC0-24hr) .
6 mg/kg/day (approximately procoralan 3 times the human exposure at the MRHD based on AUC0-24hr) . Teratogenic effects including interventricular septal defect and complex anomalies of major arteries were observed at procoralan qt procoralan medicina net procoralan und asthma procoralan dawkowanie procoralan signify doses ≥ 4 .
In pregnant rabbits, oral administration of ivabradine during the period of organogenesis (gestation day 6 18) at doses of 7, 14, procoralan or 28 mg/kg/day resulted in fetal toxicity and teratogenicity .
Treatment with all doses ≥ 7 mg/kg/day (equivalent to the human procoralan exposure at the MRHD based on AUC0-24hr) caused an increase in post-implantation loss .
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