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What were the CHMP’s main concerns that led to the refusal? The CHMP noted that the main studies showed clinically relevant weight loss following treatment with Qsiva but had concerns about the medicine’s long-term effects on phentermine the heart and blood vessels, particularly due to the effects of phentermine, which is known to increase the heart rate but whose long-term effects are not clear .
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Topiramate is also known to be potentially harmful to the unborn baby if taken phentermine by pregnant women .
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