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The renal clearance of pramipexole is approximately 400 mL/min (CV=25%), approximately three times higher than the define benicar benicar and weight gain benicar hct pi benicar problems benicar and alcohol glomerular filtration rate .
Thus, pramipexole is secreted by the renal tubules, probably by mirapex the organic cation transport system .
Pharmacokinetics in Special Populations Because therapy with MIRAPEX tablets is initiated at a low dose and gradually titrated upward according to clinical tolerability to obtain the optimum therapeutic effect, adjustment of mirapex the initial dose based on gender, weight, or age is not necessary .
However, renal insufficiency, which can cause a large avapro vs benicar benicar use buy benicar benicar lawsuit lawyers how does benicar work benicar decrease in the ability to eliminate pramipexole, may necessitate dosage adjustment (see CLINICAL PHARMACOLOGY, Renal Insufficiency) .
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