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Routine administration of vaccines or toxoids should be deferred until corticosteroid therapy is discontinued if possible [see Warnings prednisone and Precautions (5 .
10)]: Multiple cohort and case controlled studies in humans suggest that maternal corticosteroid use during the first trimester increases the rate of cleft lip with or without cleft palate from prednisone about 1/1000 infants to 3-5/1000 infants . USE IN SPECIFIC POPULATIONS Teratogenic Effects Pregnancy Category D [see what is the difference between prednisolone and prednisone what is difference between prednisone and Warnings and Precautions (5 .
Two prospective case control studies showed decreased birth prednisone weight in infants exposed to maternal corticosteroids in utero .
prednisone RAYOS was not formally evaluated for effects on reproduction .
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