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Studies in Patients with Early Parkinson’s Disease Patients (N=599) in the two studies of early Parkinson’s disease had a mean disease mirapex duration of 2 years, limited or no prior exposure to levodopa (generally none in the preceding 6 months), and were not experiencing the “on-off” phenomenon and dyskinesia characteristic of later stages of the disease .
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Patients could be on selegiline, mirapex anticholinergics, or both, but could not be on levodopa products or amantadine .
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