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Both tapentadol prolonged release and oxycodone controlled release significantly reduced mean pain intensity scores throughout the treatment period (3-week titration,12-week maintenance period) with reported mean total daily doses of approximately 350mg for tapentadol prolonged release and 70mg for oxycodone controlled release remaining stable tapentadol during the maintenance period, again yielding a dose equivalency of 5:1 .
The most common treatment emergent adverse events (≥10% patients) tapentadol in the active treatment groups were headache, somnolence, fatigue and pruritus .
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