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Flushing, drug rash, and exfoliative dermatitis have been reported in patients receiving nitrate nitroglycerin Hemodynamic Effects: The effects of nitroglycerin overdose are generally the results of nitroglycerin’s capacity to induce vasodilatation, venous pooling, reduced cardiac output, and hypotension .
These hemodynamic changes may have protean manifestations, including increased intracranial pressure, with any or all of persistent throbbing headache, confusion, and moderate fever; vertigo; palpitations; tachycardia; visual disturbances; nausea and vomiting (possibly with colic and even bloody diarrhea); syncope (especially in the nitroglycerin upright posture); dyspnea, later followed by reduced ventilatory effort; diaphoresis, with the skin either flushed or cold and clammy; heart block and bradycardia; paralysis; coma; seizures; and death .
No specific antagonist to the vasodilator effects of nitroglycerin is known, and no nitroglycerin intervention has been subject to controlled study as a therapy of nitroglycerin overdose .
Because the nitroglycerin for angina nitroglycerin ointment brand name how do you take nitroglycerin hypotension associated with nitroglycerin overdose is the result of venodilatation and arterial hypovolemia, prudent therapy in this situation should be directed toward increase in central fluid volume .
Passive elevation of the patient’s legs may be sufficient, but intravenous what does nitroglycerin do for chest pain nitroglycerin drip side effects nitroglycerin explosive infusion of normal saline or similar fluid may also be necessary .
The nitroglycerin use of epinephrine or other arterial vasoconstrictors in this setting is likely to do more harm In patients with renal disease or congestive heart failure, therapy resulting in central volume expansion is not without hazard .
Treatment of nitroglycerin overdose in these patients nitroglycerin may be subtle and difficult, and invasive monitoring may be required .
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