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Bioavailability is 5-37% largely due to first pass metabolism in the liver (less when given with food) purinethol tablets purinethol et soleil purinethol rj purinethol colitis ulcerosa dosierung Widely distributed to body tissues . purinethol oral: Incomplete and variable absorption ± 50% .
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purinethol Inactivated by TMPT and xanthine Any use of the information is subject, at all times, to CCO’s Terms and Conditions .
purinethol Renal clearance may become important at high doses . CCO Formulary – August 2016 Active metabolites purinethol thioguanine nucleotides, methylated Inactive metabolites At conventional doses clearance is primarily hepatic and by xanthine oxidase, which is the main catabolic enzyme .
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