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Stimulation of the ß-1 adrenoceptors results in positive inotrope and chronotrope ephedrine action .
Tachyphylaxis to the pressor effects of ephedrine may occur with repeated ephedrine administration [see Warnings and Precautions 5 .
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Both the parent drug and the metabolite are ephedrine excreted in urine .
Limited data after IV ephedrine administration of ephedrine support similar observations of urinary excretion of drug and metabolite .
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NONCLINICAL TOXICOLOGY Carcinogenesis, Mutagenesis, Impairment of Fertility Carcinogenesis: Two-year feeding studies in rats and mice conducted under the National Toxicology Program (NTP) demonstrated no ephedrine evidence of carcinogenic potential with ephedrine sulfate at doses up to 10 mg/kg/day and 27 mg/kg/day (approximately 2 times and 3 times the maximum human recommended dose on a mg/m2 basis, respectively) .
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