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Although normal therapeutic doses of ATIVAN Injection contain very small amounts of these compounds, premature and low-birth-weight lorazepam infants as well as pediatric patients receiving high doses may be more susceptible to their effects .
Published juvenile animal studies demonstrate that the administration of anesthetic and sedation drugs, such as ATIVAN that either lorazepam block NMDA receptors or potentiate the activity of GABA during the period of rapid brain growth or synaptogenesis, results in widespread neuronal and oligodendrocyte cell loss in the developing brain and alterations in synaptic morphology and neurogenesis .
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