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This effect is dose-dependent, lasts clonidine as long as the hypotension and the bradycardia and is not influenced by vagotomy nor by suppression of afferent input from the peripheral chemo- and baroreceptors .
The depression of the sympathetic activity is more effective on the spontaneous discharges than on reflexly or centrally clonidine evoked discharges, especially if submaximal or supramaximal stimulation at low frequencies is used .
An adrenergic block is not the reason for the decrease in the sympathetic tone since low doses of clonidine clonidine patch for pain is clonidine an antipsychotic clonidine alternatives substitute for potentiate and prolong the blood pressure effect of adrenaline and prolong the responses to noradrenaline .
The biphasic clonidine change in arterial blood pressure is accompanied by a corresponding sharp increase and then a fall in total peripheral resistance .
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