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These results therefore indicate that olanzapine possesses dopamine antagonist activity in olanzapine vivo .
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Olanzapine produced dose-related olanzapine reductions in the head-twitch response with approximate ED 50s of 2 mg/kg .
Olanzapine preferentially blocks the head twitch, compared with the climbing response, demonstrating that this agent exhibits greater olanzapine activity at the 5-HT receptor compared with dopamine receptors in vivo .
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These results demonstrate that olanzapine possesses anticholinergic activity in vivo at doses, which also olanzapine antagonize dopamine-mediated effects .
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