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A major depressive episode implies a prominent and relatively persistent depressed or dysphoric mood that usually interferes with daily functioning (nearly every day for at least 2 weeks); it should include at least 4 of the following 8 symptoms: Change in appetite, change in sleep, psychomotor agitation or retardation, loss of interest in usual activities or decrease in sexual drive, increased fatigue, feelings of guilt or paxil worthlessness, slowed thinking or impaired concentration, and a suicide attempt or suicidal ideation .
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The efficacy of PAXIL in maintaining a response in major depressive disorder for up to 1 year was paxil demonstrated in a placebo-controlled trial (see Clinical Trials) .
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