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Studies in morphine-dependent monkeys demonstrated that loperamide hydrochloride at doses imodium above those recommended for humans prevented signs of morphine withdrawal . However, in humans, the naloxone challenge pupil test, which when positive indicates opiate-like effects, performed after a single high dose, or imodium after more than two years of therapeutic use of IMODIUM� (loperamide hydrochloride), was negative . Orally administered IMODIUM� (loperamide hcl) (loperamide formulated with magnesium stearate) is both highly insoluble and penetrates imodium the CNS poorly .
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