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We noted a significant overall benefit in time-to-distant-recurrence for anastrozole (324 vs 375 events, hazard ratio 0·86, arimidex 95% CI 0·74–0·99, p=0·04), with a similar trend in the subset of hormone-receptorpositive patients (0·84, 0·70–1·00, p=0·06) .
The incidence of contralateral breast cancer was substantially reduced by anastrozole compared with tamoxifen (all patients 35 vs 59, 42% reduction, 95% CI 12–62, p=0·01; hormone-receptor-positive patients 53%, anastrozole stroke risk arimidex quitting anastrozol y fiebre arimidex quitting arimidex para que es 25–71, p=0·001) .
Since tamoxifen shows a 50% reduction in the occurrence of these tumours in hormone-receptor-positive patients compared with placebo,4 the findings from the ATAC study suggest that anastrozole treatment might arimidex prevent 70–80% of hormone-receptor-positive tumours in women at high risk of breast cancer .
831 women died; 500 (60%) after recurrence of breast cancer and arimidex 331 (40%) without recurrence and due to other causes .
Overall survival was similar for anastrozole and tamoxifen (hazard ratio 0·97, 95% CI 0·85–1·12, p=0·7); a 12% reduction in deaths from breast cancer in the anastrozole group was not significant (0·88, arimidex 0·74–1·05; p=0·2) .
However, since the arimidex trial population had a relatively good prognosis (5695 [61%] of patients were lymph-node-negative and 5959 [64%] had tumours 2 cm or smaller in diameter), it is too early to expect a difference in survival .
For example, it took at least 7 years to show a significant survival advantage for tamoxifen versus placebo in previous adjuvant arimidex studies . 5 The significant reductions in recurrence and distant recurrence associated with anastrozole strongly suggest that a reduction in deaths from breast cancer will anastrozole half life arimidex side effects after 5 years arimidex osteoporosis arimidex buy online eventually be seen .
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