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mirabilis)400 mg PO every 12 hr x 3 days Uncomplicated UTI: (other organisms) 400 mg ORALLY every 12 hr x 7-10 days Efficacy and safety not established in patients less than 18 years of age Disease state based dosing: Renal failure of CrCl < 30ml/min: noroxin 400mg PO q24h Hepatic failure: No dosing changes recommended at this time .
Contraindications/Warnings/Precautions: • Prolongation of QT interval; avoid concurrent use with other drugs that prolong QT interval and in patients with risk factors for torsades de pointes (hypokalemia, significant bradycardia, cardiomyopathy) • Patients with glucose 6-phosphate dehydrogenase deficiency • Diabetes mellitus; disturbances of blood glucose have been reported, usually in diabetic patients receiving concomitant treatment with an oral hypoglycemic agent or noroxin with insulin Drug Interactions: Divalent cations: aluminum, magnesium zinc, iron, calcium, antacids, sucralfate – reduced bioavailability of quinolones (can cause therapeutic failure) Theophylline, caffeine, xanthines: clearance of these is inhibited with fluoroquinolones Category C: Risk unknown .
noroxin prescribing information norfloxacine sandoz 400 norfloxacine zon noroxine norfloxacine 400 Human studies inadequate .
Monitoring Requirements: Therapeutic: Culture and sensitivities, signs and symptoms of infection Toxic: Urinalysis, BUN, Creatinine, AST and ALT, Physicial examination: encephalopathic Brand names/Manufacturer: CHIBROXIN (Merck Sharp norfloxacin for tooth infection norfloxacin canine dosage norfloxacine reizigersdiarree noroxin & Dohme – BRAZIL, SINGAPORE, CHILE, MALAYSIA, USA – Opthalmic solution) FLOXEN (Pharmaniaga – MALAYSIA, HONG KONG) JANACIN (Biolab – THAILAND, HONG KONG, MALAYSIA) LEXINOR (AstraZeneca – SWEDEN, HONG KONG, THAILAND, FINLAND, MALAYSIA) NOROXIN (Merck Sharp & Dohme – SOUTH AFRICA, SWITZERLAND, PORTUGAL, MEXICO, NEW ZEALAND, AUSTRALIA, CHILE, CANADA) ZOROXIN (Merck Sharp & Dohme – BELGIUM, AUSTRIA, DENMARK) .
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