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Toronto, Ontario M5W 3N7 Control#: 136545 (nitrofurantoin monohydrate/macrocrystals) USP Dissolution Test 2 THERAPEUTIC CLASSIFICATION Urinary Tract Antibacterial ACTIONS AND CLINICAL PHARMACOLOGY Nitrofurantoin is reduced by bacterial flavoproteins to reactive intermediates which inactivate or macrobid alter bacterial ribosomal proteins and other macromolecules .
As a result of such inactivations, the vital biochemical processes of protein synthesis, aerobic energy metabolism, DNA synthesis, RNA macrobid synthesis, and cell wall synthesis are inhibited .
The broad-based nature of this mode of action may explain the lack of acquired bacterial resistance to nitrofurantoin, as the necessary multiple and macrobid simultaneous mutations of the target macromolecules would likely be lethal to the bacteria .
Each MacroBID macrobid capsule contains two forms of nitrofurantoin .
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