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Blood levels of cyclosporine may be reduced when used modafinil with PROVIGIL .
Monitoring of circulating cyclosporine concentrations and appropriate dosage adjustment for cyclosporine modafinil should be considered when used concomitantly with PROVIGIL .
Effects of modafinil PROVIGIL on CYP2C19 Substrates Elimination of drugs that are substrates for CYP2C19 (e . , phenytoin, diazepam, propranolol, omeprazole, and modafinil clomipramine) may be prolonged by PROVIGIL via inhibition of metabolic enzymes, with resultant higher systemic exposure .
In individuals deficient in the CYP2D6 enzyme, the levels of CYP2D6 substrates which have ancillary routes of elimination through modafinil CYP2C19, such as tricyclic antidepressants and selective serotonin reuptake inhibitors, may be increased by co-administration of PROVIGIL .
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