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6 Renal Impairment Clearance of levofloxacin is substantially reduced and plasma elimination half-life is substantially prolonged in patients with impaired renal function (creatinine clearance < 50 mL/min), requiring dosage adjustment in such levaquin patients to avoid accumulation .
levaquin Neither hemodialysis nor continuous ambulatory peritoneal dialysis (CAPD) is effective in removal of levofloxacin from the body, indicating that supplemental doses of LEVAQUIN® are not required following hemodialysis or CAPD [see Dosage and Administration (2 .
7 Hepatic Impairment Pharmacokinetic levaquin studies in hepatically impaired patients have not been conducted .
Due to the limited extent of levofloxacin metabolism, the pharmacokinetics of levofloxacin are not expected to be affected levaquin by hepatic impairment .
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