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Simultaneous administration of fentanyl and intravenous midazolam results in an increase in the terminal plasma fentanyl half-life and a reduction in the plasma clearance of midazolam .
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Adverse Drug Reactions Reported by ≥ 1% of SUBLIMAZE-treated Subjects in 20 Clinical Trials of SUBLIMAZE System/Organ Class Adverse Reaction Nervous System fentanyl fentanyl fentanyl overdose fentanyl tooth decay fentanyl otfc fentanyl patient information Disorders Visual disturbance Cardiac Disorders Vascular Disorders Respiratory, Thoracic and Mediastinal Disorders Gastrointestinal Disorders Skin and Subcutaneous Tissue Disorders Dermatitis allergic Musculoskeletal and Connective Tissue Disorders Muscle rigidity (which may also involve the thoracic Injury, Poisoning and Procedural Complications Confusion postoperative Anaesthetic complication neurological Additional ADRs that occurred in <1% of SUBLIMAZE-treated subjects in the 20 clinical trials are listed below in Table 2 .
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