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The most common treatment emergent adverse events (≥10% of patients in either treatment group) were constipation, nausea, tapentadol dizziness, somnolence, vomiting, headache, fatigue and pruritus .
6%) than in the oxycodone controlled release group tapentadol (21 . The incidence of gastrointestinal treatment emergent adverse events, including nausea, vomiting or constipation, that led tapentadol to study discontinuation was lower in the tapentadol prolonged release group (8 .
For patients completing the study, the mean total daily dose of both tapentadol prolonged release and oxycodone controlled release increased sharply during the first 4 weeks of the treatment period (dose titration), then remained approximately stable at tapentadol prolonged release 390mg and oxycodone HCl controlled release 74mg for the remainder of the study giving the same approximate dose equivalency of 5:1 as reported tapentadol by Buynak et al16 .
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